Natasha Lyonne was born Natasha Braunstein into a conservative Jewish family on April 4th, 1979 in New York City and spent her childhood in New York and Israel. Natasha's brother, Adam served in the Israeli army and her father is Aaron Braunstein - a major boxing promoter and entertainment agent. Natasha attended Yeshiva high school, which is a Jewish high-school in Manhattan, New York.

Whilst Natasha was there, she acted in many school productions. One being The Magic Garden. Natasha has starred in many movies, including Dennis the Menace (1993), Everyone Says I Love You (1996), Slums Of Beverly Hills (1998), Scary Movie 2 (2001) and Kate & Leopold (2001).